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• Archaeologists found a huge amount of litharge - a lead oxide and by-product of silver extraction - which suggests a clan was melting down metal to get at its precious material.

• The excavation and subsequent research, which was led by Pre-Construct Archaeology (PCA) and involved archaeologists from Newcastle University, revealed a rectangular building which would have been built from timber and divided internally by three aisles. This type of multi-function "aisled" building was fairly common in Roman Britain and would have been used both as a house and place for crafts. However, although the archaeologists found evidence of small-scale metalworking at one end of the building, it was not at a level that would have produced the amount of litharge discovered.

• Targeted Drug Delivery System using Acoustic Lens-attached US (LENS) and Sonoresponsive Liposomes. Schematic of the target-specific drug delivery system by acoustic lens-attached US system (LENS) with the antitumor drug-loaded sonoresponsive liposome carrier (IMP301). Upon reaching the target tumor region through the microvasculature, disrupted IMP301 releases an antitumor drug by FUS exposure and MB oscillation.

• The label for irinotecan liposome comes with a boxed warning, noting a risk for severe or life-threatening neutropenia and diarrhea.

• "As a result of work with the detained terrorists, examination of the technical devices seized from them and analysis of information on financial transactions, evidence of their links with Ukrainian nationalists has been obtained," Russia's Investigative Committee said on Thursday.

• Direct and relayed links are eligible for use in Eurosystem credit operations if they comply with the eligibility criteria.

• Through the fourth amendment to the Patent Law of China in 2020, China established its own pharmaceutical patent linkage system. In December 2021, the Beijing Intellectual Property Court accepted the first pharmaceutical patent linkage lawsuit and issued its decision on April 15, 2022. This presentation will discuss China’s new pharmaceutical patent linkage system, including the legislative process and its current operation in practice. Topics will cover: 

• Text description provided by the architects. The clients came to us at a pivotal stage in their lives as soon-to-be empty nesters. The evolving needs of a family became the impetus for how we imagined a house that could embody the state of transition at a conceptual and experiential level. We chose the word liminal to encapsulate ideas that have informed the design process: namely the feeling of inhabiting a transitory place; orchestrating movement through space, and dwelling in the moments between from and to...

• a Distribution of the number of categories of ligands identified for each E3 ligase from multiple data sources. b Chord chart for E3 ligases with 3 types of ligands. c Circular barplot representing the distribution of unique ligands of E3 ligases. d E3 ligases with top number of unique ligands and one dot representing 1000 ligands. E3 ligases in red were proceeded to PROTAC clinical trials. E3 ligases in blue were explored in PROTAC experiment.

• HeLa cells, displaying a functional cGAS–STING pathway, were used for most of the experiments. U2OS cells, expressing cGAS, were used to independently validate hits obtained from the siRNA screen. HEK293T cells were used for immunoprecipitation and ubiquitylation studies using transiently expressed tagged constructs. BJ-5ta cells, THP-1 cells and primary endothelial cells were used to ascertain the relevance of cGAS nuclear degradation by the CRL5–SPSB3 ubiquitin ligase across distinct cell types and primary human cells. Cell lines were repeatedly tested for mycoplasma by PCR. No method of cell line authentication was used.

• A jury in New York found former NRA gun lobby chief Wayne LaPierre liable on Friday, February 23, for corruptly mismanaging the organization, US media reported. Lapierre and a senior executive of the National Rifle Association must pay a penalty of $6.35 million "for years of corruption and greed," said state Attorney General Letitia James.

• While not wavering in its belief that there was not full-scale lewisite production in Willoughby, the Corps last month included $100,000 in its current budget for an archived photographic analysis and historical site assessment of the location this year.

• They also supplied some 750,000 bottles of phenacyl chloride inhibitors to treat poisoning with mustard gas, lewisite and hydrocyanic acid derivatives.

• Cette différence s'explique par le type de leuconychie (« Leukonychia and Other Nail Discoloration: An Overview », publié dans la revue Syndromes : Rapid Recognition and Perioperative Implications en 2019). En effet, il peut s'agir d'une leuconychie véritable : dans ce cas-là, les taches blanches prennent naissance dans la matrice de l'ongle. En revanche, en cas de leuconychie apparente, les taches blanches ne sont pas dans l'ongle, mais au niveau du lit de l'ongle, la partie de l'ongle qui se trouve sous l'ongle. En termes de classification, les médecins répertorient quatre types de leuconychies véritables :

• These porcelains or ceramics are generally reinforced with leucite. Multiple firings will increase leucite content and the CTE. So really we only have a few attempts to get it right.

• Hajjaran, H. et al. Detection and molecular identification of leishmania RNA virus (LRV) in Iranian Leishmania species. Arch. Virol. 161, 3385–3390 (2016).

• Mandell, M. A. & Beverley, S. M. Concomitant immunity induced by persistent leishmania major does not preclude secondary re-infection: implications for genetic exchange, diversity and vaccination. PLoS Negl. Trop. Dis. 10, e0004811 (2016).

• "All patients who suffer from suspicious symptoms are examined by a military dermatologist, receive appropriate treatment and are referred to a dedicated leishmania clinic as needed,” he added.

• Paola Manzotti, Michel Ballèvre, Pavel Pitra and Federica Schiavi, 2021. Missing lawsonite and aragonite found: P–T and fluid composition in meta-marls from the Combin Zone (Western Alps). Contributions to Mineral and Petrology: 176, 60. https://doi.org/10.1007/s00410-021-01818-0

• Schmidt, M. W. & Poli, S. The stability of lawsonite and zoisite at high pressures: experiments in CASH to 92 kbar and implications for the presence of hydrous phases in subducted lithosphere. Earth Planet. Sci. Lett. 124, 105–118 (1994)

• Eliav, E., Kaldor, U. & Ishikawa, Y. Transition energies of ytterbium, lutetium, and lawrencium by the relativistic coupled-cluster method. Phys. Rev. A 52, 291–296 (1995)

• The thief (or thieves) had seized the works from the gallery walls at night and removed the fragile watercolours from their frames. They were then rolled up in a cardboard tube, with the Van Gogh protruding out of one end. The tube was later abandoned, by being lent against the closed lavatory building, beside sodden leaves and litter. It had been a rainy day and a police statement described the weather as “extremely bad”.

• Le sous-sol par de vastes escaliers, bien éclairés, donnera des communications souterraines avec les rives opposées des deux boulevards. L’importance superficielle de ce refuge permettra en outre de distribuer le reste du sous-sol en lavatory (lisez cabinets de toilette), à l’instar de ceux de Londres : For ladies and gentlemen.

• “After almost six months, … the vote, almost unanimous,” has demanded a lasting and immediate ceasefire in Gaza.

• Eurasia was especially hit harder with longer lasting heat waves, the study said. Heat waves slowed down most in Africa, while North America and Australia saw the biggest increases in overall magnitude, which measures temperature and area, according to the study.

• The Secretary-General’s appeal for a lasting peace and a humanitarian ceasefire to enable the effective delivery of food, fuel and medicines came as the UN agency for Palestinian refugees, UNRWA, confirmed that it had been barred by the Israeli authorities from transporting assistance to northern Gaza.

• Meanwhile, they will operate from the WISH shop at 4 The Parade, Kidlington, on Fridays and Saturdays, offering the larder and a less extensive climatarian kitchen service.

• Une nouvelle espèce de singe a été découverte en Birmanie. Le petit primate, dont le corps mesure entre 50 et 60 centimètres, a été baptisé popa langur par les chercheurs du Centre de primatologie allemand (DPZ) et de l’ONG environnementale Fauna and Flora International (FFI), qui l’ont identifié après de longues recherches.

• Those black rocks, called lamprophyre dikes, were intruded as molten lava in cracks below the surface and although there may have been some surface expressions, there were no proper volcanoes.

• As they evolved against a backdrop of aridification and replacement of C3 dominated woodland with C4 dominated grassland, lamellation and hypsodonty took effect and tooth size increased.

• New Delhi: The procurement of goods and services through government’s portal GeM has crossed Rs 4 lakh crore so far this fiscal due to higher buying activities by various ministries and departments, a senior government official said on Friday.

• The prices of Thai commodities in Myanmar are rising again due to the value of the Myanmar kyat falling steeply against the Thai baht in the last month and transport problems.

• However, on average, the depreciation of the kwanza will be much slower than in 2024 (from an average of 12.9% in 2023 to 4.8% in 2024) as we expect that central banks in DMs will embark on a monetary easing cycle next year. This will encourage capital flows to EMs and reduce support for the US dollar, offering some support for EM currencies such as the kwanza.

• And they certainly are fascinating stories as to bring a new stone to the display cabinets of 5th Avenue was an adventure not for the faint-hearted.  Travelling the world to find new stones to delight Tiffany's customers, a lilac-pink stone found in California was named for the ground-breaking gemologist Dr Kunz and kunzite was first seen in Tiffany jewels in 1920. Morganite, with a shimmering pink hue, was named for the famous banker John Pierpont Morgan who was a devoted customer of Tiffany and a great lover of gemstones. The stone was discovered in Madagascar and introduced into the world of jewellery by Tiffany in 1910.

• A look at the latest jewels to leave the workshop gives evidence of this privileged access to the finest that the earth has to offer.  The new collection pairs vibrant clusters of gemstones in luscious colours sourced from the best European gem cutters with cool and creamy baroque pearls from under the waves of Australia’s remote Northern Territory.  Native opals meet superior kunzite or unusual unheated green Paraiba tourmalines from Brazil.

• The Ministry of Finance of the Taliban reported that a significant amount of kunzite and lithium ore was intercepted at the "Torkham" border crossing in Nangarhar province. The smugglers had concealed the illicit goods in truck beds, camouflaging them with coal.

• Three katanas and a kukri were seized as case exhibits.

• ANN/THE STRAITS TIMES – Three men aged between 22 and 35, were arrested for the alleged illegal possession of weapons including a kukri (knife) and three katana (swords).

• Valorant: The playable character Reyna utilizes a kukri as her signature weapon, showcasing her deadly and agile combat style.

• As well as kochia balls, cosmos flowers are in full bloom from early to late October, and fields are next to each other! It’s paved around flower fields so enjoy walking around those cute and colourful flowers and plants!