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• The Allegheny County Police Department and county fire marshal are requesting the public's help to identify a man who could be connected to the deadly Rustic Ridge house explosion from last year.

• Max became margrave — which Debrett's defines as the German rank of count — upon his father's death, and was instrumental in the revitalization of Lake Constance land which led to the flourishing Markgraf von Baden winery.

• Ishizaki, K., Nishihama, R., Yamato, K. T. & Kohchi, T. Molecular genetic tools and techniques for marchantia polymorpha research. Plant Cell Physiol. 57, 262–270 (2016).

• Akashi, H., Okamura, E., Nishihama, R., Kohchi, T. & Hirai, M. Y. Identification and biochemical characterization of the serine biosynthetic enzyme 3-phosphoglycerate dehydrogenase in marchantia polymorpha. Front. Plant Sci. 9 (2018).

• We knew that marcescence had been relatively well researched in arid ecosystems, in which solar radiation strongly degrades difficult-to-decompose compounds in retained biomass. This facilitates decomposition of and nutrient release from that biomass once shed, with potential competitive advantages for the respective plants.

• Former Miami Dolphin and NFL star Vontae Davis was found dead inside a Southwest Ranches mansion on Monday, authorities said.

• Farmer William Brown’s attempt to register manorial rights over Aldbourne sports field and Palmers Field has met opposition from the parish council.

• In a recent report, the Commons’ All-Party Justice Select Committee called on the Government’s legal advisers to review the operation of manorial rights. The report said there were fears homeowners could be saddled with significant legal fees over disputed manorial claims, which could also delay property sales, and potentially affect house prices.

• Exploiting ancient manorial rights in Britain to go hunting, fishing and shooting over other people’s land, could soon be outlawed, MPs have suggested.

• The Manorial Society aims to promote the study of English history and traditions, especially the monarchy and British parliamentary institutions and the preservation of manorial records.

• Dairy milk production has increased manifold in eastern Nangarhar province this year due to growing number of dairy farms and proper feeding, Canal Project officials . . .

• Prodi, A. et al. Charge, orbital and spin ordering phenomena in the mixed valence manganite (NaMn3 3+)(Mn2 3+Mn2 4+)O12. Nat. Mater. 3, 48–52 (2004).

• The business manganate has kept his salary capped at Rs 15 crore since 2008-09 forgoing commission of nearly Rs 24 crore annually. In comparison, other directors and top executive at the company saw handsome raise in their annual salary at the financial year ending on March 31, 2018.

• A “realistic” obese manakin has been developed to help educate further nurses and healthcare professionals.

• "All you ever wanted was to be a mammy and what an amazing mammy you were.

• Le scénario à l'emporte-pièce raconte, d'une part, le combat de Zinos pour transformer son boui-boui, jusque-là fréquenté par une poignée d'ouvriers malcommodes, en établissement plus raffiné grâce à un chef caractériel hostile aux fish and chips et autres schnitzels.

• The California-based biotech uses its combination of AI and chemistry expertise to “address the complexities of medicinal chemistry in the macrocycle space,” the company said in a Jan. 23 release. Now, Merck has tapped up UNP to apply its tech to develop macrocyclic candidates against a “challenging” undisclosed oncology target.

• Investors are coming to similar conclusions about other macrocycle firms. The California start-up Insamo recently announced that it has secured $12 million in seed funding to develop small, orally available and cell-permeable cyclic peptides using artificial intelligence protein design expertise. The UK start-up Curve Therapeuticsjust raised about $52 million in series A funding for what it calls its “microcycle” platform.

• They said that only earth work was carried on the road and after the passage of over eight years no macadamisation or other repair work has been taken up.

• ORF3a blocked the retrieval of CI-M6PR from Rab7-positive endosomes to the TGN and, consequently, impaired the sorting of newly synthesized lysosomal hydrolases from the TGN. ORF3a expression and SARS-CoV-2 infection also impaired the fusion of Rab7-positive compartments with Arl8b and LAMP1-positive compartments that mediate virus egress from host cells. Taken together, our results suggest that SARS-CoV-2, through its accessory protein ORF3a, blocks Rab7 GTP-GDP cycling, which impairs lysosome fusion with other compartments and rather promotes the egress of the virus via lysosomal exocytosis.

• PRINCETON, N.J. - Bristol Myers Squibb (NYSE: BMY) a annoncé aujourd'hui que la Food and Drug Administration (FDA) américaine a accordé une autorisation accélérée à Breyanzi (lisocabtagene maraleucel ; liso-cel), une thérapie cellulaire CAR (chimeric antigen receptor) dirigée contre le CD19. Cette autorisation permet le traitement de patients adultes atteints de leucémie lymphocytaire chronique (LLC) ou de lymphome lymphocytaire de petite taille (SLL) en rechute ou réfractaire, ayant reçu au moins deux traitements antérieurs, dont un inhibiteur de la tyrosine kinase de Bruton (BTK) et un inhibiteur du lymphome à cellules B 2 (BCL-2).

• As well as the obvious danger of bombs, many of the female munitions workers suffered illnesses which later proved fatal, caused by exposure to lyddite and amatol explosives.

• In ancient times, the purity of precious metals was gauged using a touchstone: a small tablet of dark fieldstone, slate or lyddite on whose finely grained surface soft metals such as gold left a visible trace. From its earliest known use by the Harappan civilisation of the Indus Valley, this simple test of authenticity travelled to Europe and beyond, its symbolism as well as its practical application intriguing philosophers of every epoch, from classical Greece to the modern era.

• With information about the relationship between carbon dioxide, lycophyte characteristics, and relative carbon isotope abundance, the researchers estimated the CO2 content of the air in which 66 fossil lycophytes grew. The fossils were diverse, representing three lycophyte genera from 13 geological deposits at nine distinct localities.

• In their quest to unravel this mystery, the researchers analyzed the genomes of two lycophyte species: Huperzia asiatica and Diphasiastrum complanatum. 

• Researchers from the Leibniz Institute for Food Systems Biology at the Technical University of Munich (LSB) have identified the odorants responsible for the characteristic lychee note of Muscaris grapes. The white Muscaris grape variety was bred in 1987 by the Freiburg State Viticulture Institute and combines the excellent fungal resistance of the Solaris variety with the intense aroma of the Yellow Muscat.

• The ratios of released reducing sugars were found to be: alginate lyase versus three-enzyme mixture = 101.3%; alginate lyase versus laminarinase = 136.6%, and alginate lyase versus fucosidase = 1242%. Regarding the above values, the alginate lyase ID 22 was selected as the most active enzyme for the degradation of L. digitata cell wall.

• a, DMSP and DMSOP lyase activities from model organisms with known DMSP lyases. The complement of ddd genes found in tested bacteria are indicated in parentheses. b, DMSP and DMSOP lyase activities of Ddd and Alma enzymes expressed in E. coli BL21. Data are presented as mean ± s.d. (n = 3).

• Two years ago, Wayward head brewer Shaun marked the birth of his son Austin by brewing Wayward Son, a West Coast IPA bursting at the seams with lupulin hop powder. Of course, an IPA isn’t the kind of beer you cellar away to revisit each year in celebration, so instead Wayward returns to brewing fresh batches of the celebratory beer. But, just as Shaun’s son has grown and changed (I assume), so has Wayward Son - it’s juicy and hazy as all get-out.

• In the case of reinvesting investment funds and investment funds with very low distributions, investors are supposed to pay tax on a notional minimum income each year, the so-called advance lump sum. This usually happens on the first working day of the new calendar year - usually 2 January.

• The concept draws from the notion of ‘learning from nature’, not only involving imitation but also embracing natural light as a guide, capturing the nuances of light and shadow and reinterpreting nature in a simple and organic manner. The ever-changing surface, informed by the play of light gradually unfolds during the day. The louver shadows silently record the passage of time, as the building cleverly utilizes natural light to reproduce the vibrant essence of the Fuchun landscape.

• • Clarification of, and the provision of additional details on, louver core-area measurement.

• In coordination with the AONL Foundation and Joslin Insight, five longitudinal studies have been conducted since 2020. The collective data are a fascinating avenue into the hearts and minds of nursing leaders and how they perceive the healthcare industry and nurses’ places in it.

• At present, means till March 31, 2024, nodal offices across central and state governments, in addition to pension-related autonomous bodies, will have to use password-based login mechanisms for NPS transactions. However, users will be required to undergo Aadhaar-based login authentication from April 1.

• Once the 3D images had been processed, the volume of each segmented lobule was defined by computing the total number of voxels of the watershed mask, which was translated into a physical volume. The contact surface between each pair of segmented lobules was also computed as the voxels having a distinct label from their neighbours and whose labels corresponded to those of the pair of lobules considered.

• GWINNETT COUNTY, Ga. — Sometimes you fight fire with fire, and sometimes you must fight a front-end loader with another front-end loader.

• The 275 hp (205 kW) crawler loader has an operating weight of 65,901 lb (29 892 kg) and replaces the 973K worldwide. It joins the 953 (160 hp/119 kW) and 963 (202 hp/151 kW) in the Cat track loader line.

• Hiab, part of Cargotec, has received a large order of EUR 5 million for loader cranes to be used in offshore wind turbines. The order was booked in Cargotec’s Q1 2024 orders received and will be delivered during 2024.  

• A High Court judge has made a recommendation to the attorney general that a struck off solicitor be declared a vexatious litigant following almost two decades of litigation against the Law Society and the Solicitors Regulation Authority.

• Aubrite falls in rare achondrite group of meteorites. Aubrites have sulphides of sodium, titanium, manganese, chromium and calcium. These are all lithophile elements.