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• Immunofluorescence studies (S protein-specific antibodies) from each syncytium indicate a very high infection level. We could not find any syncytial cells in mildly infected patients. However, identical (neutrophils or type 2 pneumocytes) and heterotypic (neutrophils-monocytes) plasma membrane initial fusion (indicating initiation of fusion) was observed under TEM in moderately infected patients. Fully matured large-size (20–100 μm) syncytial cells were found in severe acute respiratory distress syndrome (ARDS-like) patients of neutrophils, monocytes, and macrophage origin under SEM.

• Here, we report using plaque unit forming titration, qPCR, immunofluorescence, and transmission electron microscopy that these isolates infect cells derived from a malignant human glioblastoma (U251 line). However, DENV3 MG-20 infected these cells with syncytium formation and cell death, while DENV3 PV_BR infected cells without syncytium formation or any other cytopathic effect (CPE) evidenced by optical microscopy. These results emphasize the difference in biological characteristics of these isolates, which could be a critical component in the interaction with the host cell and the development of severe dengue.

• A 23-year-old woman with past medical history of bipolar II disorder and a REM-specific seizure disorder that resolved at age 9 presented after a syncopal episode. The patient reported an initial sensation of lightheadedness while at work, which was followed by a syncopal episode with brief (1-2 min) loss of consciousness and a minor head injury.

• On the admission day, the patient was coughing repeatedly at home. After a vigorous cough he had a syncopal episode. Right after this, the patient was brought to the emergency department (ED) and admitted for syncope workup.

• This was reported to the entire world by the Pravda newspaper on 11 April 1957. The later date was due to the fact that the event took place only after the accelerator’s energy gradually raised since the commissioning day and exceeded the energy of 6,3 GeV of the then leading American synchrophasotron in Berkeley. “8,3 billion electronvolts reached!” the newspaper reported and thus announced that a record accelerator had been created in the Soviet Union.

• Giuseppe was assigned to the Synchrocyclotron Division.  This was the first accelerator built at CERN and was operated from 1957 until 1990. Giuseppe set up a group and prepared the basic equipment for experiments that was used in 1958 for a successful search for pions decaying into an electron and a neutrino. This was a hot topic at the time and was the first experiment involving a CERN accelerator. "The news went all over the world overnight," recalls Giuseppe. Recently refurbished, the synchrocyclotron will soon become a permanent exhibit at CERN.

• Cotton bolls were collected from the 10 mature plants of each experimental unit, and average boll weight was determined by dividing total seed cotton yield per plant to the total number of bolls. Number of sympodial branches per plant were calculated from 10 randomized selected plants of each experimental unit.

• Histological findings were reported as follows: "Direct potassium hydroxide (KOH) microscopic examination from skin scrapings revealed branched brown hyphae with light brown septa. A fungal culture on Sabouraud's agar media produced wet, medium brown, yeast-like colonies, the surface of which later became black and shiny. A slide culture disclosed light brown, elliptic or peanut-shaped conidia comprised of one to two ampullaceous cells. Scanning electron microscopic examination of the conidia showed both annellation [sic] conidia with lunate bud scars and sympodial conidiogenesis."

• Interestingly, strawberry inflorescences combine two branching systems – a monopodial primary axis and sympodial lateral branches – and are botanically known as thyrses. The development of thyrse architecture has not been previously explored in any other plant.

• When you think of a mine, you may picture grimy, black soot and sickening dust. But the walls of Berezniki, Russia's sylvinite mine hold layers of red, blue and orange. The rainbow walls are created by potassium-rich sylvinite deposits that formed millions of years ago, when ancient underground oceans dried up, leaving beind rock and salts. 

• As of February 2021, the proven and probable reserves at the Tugaske project were estimated at 34.93Mt of sylvinite and 14.53Mt muriate of potash (MOP) with a combined grade of 42.26% potassium chloride (KCl).

• This free to play sweepstake generator has been created in association with Racing Welfare who work to support current and retired racing staff, and their families through professional help and practical guidance.

• This category includes both the initial welcome bonus offered by a sweepstakes casino and the promotions it offers to existing players. We carefully evaluate each sweepstake casino’s bonuses and promotions to find the very best for our readers. 

• Le Figaro newspaper reported that the government wanted children to wear a white or grey polo shirt, blue sweater and grey pants. This was confirmed to AFP by a government source. Local authorities will, with some conditions, be able to choose their own uniforms, but the government has proposed its colors. According to Le Figaro, half the cost of each child's uniform will come from public money.

• Interdigitation, midpalatal suture density ratio, and density of the sutural area relative to hard tissues may not be useful indicators of midpalatal suture maturation.

• The Olympic dream has been one that the Numa family have always aspired to and its every parents dream to see their children excel in a vocation they choose to be surpassable in.

• Pour expliquer cette surmédicalisation des enfants, Céline Lamy montre du doigt la manière dont est utilisé le Diagnostic and Statistical Manual of Mental Disorders (DSM), un ouvrage qui répertorie tous les troubles psychiatriques, et qui est largement utilisé au Québec. Lors de sa publication en 1952, on y recensait environ 60 pathologies différentes. Chaque nouvelle version contient de nouveaux troubles — l’homosexualité y avait d’ailleurs été introduite en 1968, avant d’être retirée quelques années plus tard. Pour chaque trouble, on établit un nombre de critères auquel doit répondre le patient pour qu’on puisse établir un diagnostic.

• In the 1980s, water along the coast was sealed off in supralittoral ponds for commercial shrimp farming. In 1994, a government order, passed without discussion, declared the entire coast open for shrimp farming. This brute-force displacement of coastal agriculture by commercial farming not only did away with agricultural communities’ basic right to work, it also cost them their rights to water, marshes, forests and land. Virtually overnight, work that for centuries had been guaranteed for a multigenerational multitude was now held by a handful of people employed in shrimp farms.

• • Mr Ong's lawyers will argue that Section 377A "violates human dignity" and that sexual orientation "is unchangeable or suppressible at unacceptable personal cost".

• Beijing WeLion New Energy Technology, a supplier of semi-solid-state batteries to Nio (NYSE: NIO), and an electric vehicle (EV) unit of Anhui Jianghuai Automobile Group (JAC) have reached an agreement to jointly develop long-range cars.

• Nexans awards the status of preferred supplier only to suppliers with a good CSR performance, among other strengths, and supports suppliers that improve their CSR performances in a continuous and sustainable way. Nexans reserves the right to delist a supplier that does not comply with the CSR principles.

• To support this growth, Materne realized it needed to grow its supplier network, adding layers of continuity to support new products and protect against supply chain disruptions.

• "We assessed sugar preferences and intestinal sucrase activity of Australian specialist and generalist nectarivores for comparison with published data from other nectarivorous bird species and compared laboratory data with foraging records from the wild," Ms Napier says.

• There have been rare reports of acute rhabdomyolysis with hyperkalemia followed by ventricular dysrhythmias, cardiac arrest and death after the administration of succinylcholine to apparently healthy pediatric patients who were subsequently found to have undiagnosed skeletal muscle myopathy, most frequently Duchenne's muscular dystrophy.

• Interest in the case was renewed after an analysis of Franco's tissue samples revealed the presence of succinylcholine and morphine, neither of which were ordered by her doctors, St. Louis Public Radio reported.

• Potapov AG, Shundrina IK. Effect of aliphatic diols and dicarboxylic acids on the properties of ethylene succinate copolyesters. Polym Sci Ser A 2019;61:544–54.

• The effect was discovered by Xiaobing Zhang and Anthony van den Pol of the Yale School of Medicine in Connecticut, whose research has focused on the zona incerta (ZI), a horizontally elongated section of grey matter located in the brain’s subthalamus region.

• The subthalamus acts as a control center for the peripheral nervous system, which encompasses all your nerves. It’s also responsible for stimulating the thalamus, somatic motor function, and assisting with vision.

• In a filing with Bursa Malaysia, Econpile said the job will entail undertaking the construction and completion of site clearing, earthworks, substructure and structure works for a five-storey basement car park, including the floor slab of lower ground 2 at the building.

• For months now, legal experts have been translating and outlining the necessary steps for industry to take in preparation for MOCRA's implementation. These range from creating an adverse event reporting system, and maintaining current and complete safety substantiation records, to ensuring facilities are registered with the FDA and more; see our full checklist, here.

• To support cosmetic and personal care product manufacturers and suppliers in navigating this requirement under MoCRA, Paula Brock, PhD, MSCI of EAS Consulting Group, has presented a seminar on Cosmetics Safety Substantiation. In addition to attending the seminar, CosmeticsDesign followed up with Dr. Brock for her critical takeaways regarding what industry companies need to know to ensure cosmetic safety substantiation compliance. 

• On April 28, 2023, the Internal Revenue Service’s (IRS) Office of Chief Counsel released guidance reiterating claims substantiation rules for health flexible spending arrangements (health FSAs) under Internal Revenue Code Section 125 and frowning upon certain substantiation practices that seem to have crept into common usage.

• The rebirth of today’s Experimental Forest began during the Great Depression with the enactment of President Franklin D. Roosevelt’s New Deal program, which enabled the federal government to buy submarginal farmland. The U.S. Forest Service and Bureau of Land Management took over responsibility for managing much of this acreage. The government requested entities, such as municipalities and universities, to submit proposals for management of the remaining submarginal lands.

• Through everything from single-celled microorganisms and Bay oyster colonies to the ocean’s sublittoral zone, Berkeley-based artist Tanja Geis explores that value. Her meditative underwater videos, for example, direct attention to what we often overlook, and her totem-like paintings using Bay mud blur the distinction between subject and medium. Geis’s art invites viewers to linger, ponder, and question what they see.

• UAV orthomosaic of the chinstrap penguin (Pygoscelis antarcticus) colony at Cabo Cariz (Nelson Island): (a) showing the guano‐covered areas with occupied nests (red polygons) where individuals were counted, and (b) an area in the sublittoral zone close to the shoreline with no occupied nests where individuals were not counted.

• Evidence collected from human genetic studies indicates a clear genetic variation between North and South Europe. Ancient DNA analyses also indicate genetic admixture within Europe. Despite this evidence, European ancestry populations are mostly regarded as stratified and not as admixed at the subcontinental level.

• The singularity of this experiment lies in the fact that the team has managed to bring the strontium gas to the quantum regime, place it in an optical lattice where the atoms could interact by collisions, and then apply the single atom imaging techniques. These three ingredients altogether make ICFO's strontium quantum-gas microscope unique.

• Mehrabi, H., Navidtalab, A., Enayati, A. & Bagherpour, B. Age, duration, and geochemical signatures of paleo-exposure events in Cenomanian-Santonian sequences (Sarvak and Ilam formations) in SW Iran: Insights from carbon and strontium isotopes chemostratigraphy. Sediment. Geol. 434, 106136 (2022).

• Two minor accidents near the Kala Academy to Balbhavan stretch have resulted in a slowdown of traffic in the area. The incidents, which involved three four-wheelers and a self-accident, occurred at separate locations along the road. These accidents have resulted in traffic congestion along this road. Watch. 

• The Lycra Company has launched a stretch denim shaping technology that aims to provide a unique fit solution for shapes and body types.