Phagosome

Définitions de « phagosome »

Phagosome - Nom commun

• (Anatomie) Organite résultant de la phagocytose au sein d'une cellule phagocytaire.

  Dans le processus de la phagocytose, la cellule phagocytaire engloutit une particule étrangère, formant un organite appelé phagosome qui agit comme une prison cellulaire pour le matériel indésirable.

Évolution historique de l’usage du mot « phagosome » depuis 1800

Citations contenant le mot « phagosome »

• La bactérie de la tuberculose (colorée en bleu) parvient d'abord à sortir du phagosome où elle se cache dans le macrophage. Lorsqu'il est détruit, elle devient violette. La bactérie parvient alors à détruire la membrane externe du macrophage. Lorsque cela se produit, il devient vert et après plusieurs dommages, le macrophage meurt finalement et libère la bactérie. © Gemini Forksing

• Since PLPs are expected to distribute uniformly within cells when added, the observed difference in the distribution is considered to have occurred during the 24 h while the samples were allowed to stand in the incubator. Namely, some mechanism of autophagy may have caused the difference in the PLP-accumulated phagosome distribution. Therefore, we conducted experiments to further clarify the observed processes.

• Dendritic cells are specialized antigen-presenting cells. As such, they exhibit limited degradation of phagocytosed antigens, which favours efficient antigen presentation to T lymphocytes. Work now shows that the restricted proteolysis is due to alkalinization of the phagosome through Rab27a-dependent fusion with a subset of lysosomal vesicles bearing NADPH–oxidase complexes.

• Phagocytosis has essential functions in immunity. Here we highlight the presence of a subcellular level of self–non-self discrimination in dendritic cells that operates at the level of individual phagosomes. We discuss how engagement of Toll-like receptor signaling controls distinct programs of phagosome maturation. An inducible mode of phagosome maturation triggered by these receptors ensures the selection of microbial antigens for presentation by major histocompatibility class II molecules during the simultaneous phagocytosis of self and non-self.

• Both V-ATPase and cathepsin D were reported to be excluded from the phagosome by Leishmania through manipulation of synaptotagmin-V dependent procedure39. In our study we observed that inhibition of only cathepsin D using pepstatin A did show some degree of inhibition in phago-lysosome fusion in ALS pre-treated MΦs, whereas inhibition of V-ATPase by bafilomycin A1 significantly hampered the process (Fig. 7A) (P < 0.05). This indicated that induction of acidification of phagosomes loaded with PLD is much critical for phago-lysosomal biogenesis in ALS pre-treated MΦs.

• Via, L.E. et al. Effects of cytokines on mycobacterial phagosome maturation. J. Cell Sci. 111, 897–905 (1998).

Traductions du mot « phagosome »

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