Galactitol

Définitions de « galactitol »

Galactitol - Nom commun

• (Biochimie, Biologie, Médecine) Alcool de sucre synonyme de dulcitol.

  Le dosage du galactitol sanguin et urinaire est élevé et le reste malgré le traitement.

Évolution historique de l’usage du mot « galactitol » depuis 1800

Citations contenant le mot « galactitol »

• Ces deux substances, le galactitol et le galactonate, doivent permettre d'analyser directement l'activité lactasique dans le corps humain, explique jeudi dans un communiqué Agroscope, qui a mené ses recherches avec le Centre hospitalier universitaire vaudois (CHUV).

• Lactose et galactose contribuent à dégrader les protéines de l'œil par accumulation d'un dérivé (galactitol) ; d'où la recommandation de ne pas trop manger de laitages. "Le cuivre, parfois donné dans des compléments antioxydants, a un effet pro-oxydant aggravant, ajoute le Dr Curtay. Si l'on prend un complexe contenant de la lutéine avec des vitamines E et C, vérifier qu'il n'en contient pas."

• In a study in children with Galactosemia aged 2-17, treatment with AT-007 demonstrated clinical benefit on activities of daily living, behavioral symptoms, cognition, fine motor skills and tremor. Govorestat also significantly reduced plasma galactitol levels in both adults and children with Galactosemia. Galactitol is a toxic metabolite responsible for tissue damage and long-term complications in Galactosemia.

• The company stated that the drug has significantly reduced plasma galactitol levels in adults and children with Galactosemia compared to placebo in clinical trials.

• “We thank the FDA for their productive feedback and for their partnership in this process,” said Riccardo Perfetti, MD, PhD, Chief Medical Officer of Applied Therapeutics. “We believe that the clinical efficacy demonstrated to date, combined with galactitol biomarker data and a favorable safety profile, provides us with a solid filing package to the FDA. We are excited to advance towards a regulatory submission for the first potential treatment for Galactosemia.”

• The results in normal animals were similar whether the isotope was injected into nonfasted animals or into animals fasted 12 h before the urine collection. Only small amounts equaling about 1% of the dose of 10 μmol were excreted as galactose or galactonate. No labeled galactitol was detected (<0.001 μmol/mouse). Very small amounts of [12C]galactose and [12C]galactonate were found.

• “Govorestat has demonstrated consistent results on improvement in galactitol biomarker levels in both adults and children and on long-term clinical and functional outcomes in children with Galactosemia,” said Riccardo Perfetti, MD, PhD, Chief Medical Officer of Applied Therapeutics. “We would like to thank all of the patients, investigators, and caregivers who participated in the ACTION-Galactosemia Kids study.”

Traductions du mot « galactitol »

Sources et ressources complémentaires

• Définitions du Wiktionnaire