Encapsidation

Définitions de « encapsidation »

Encapsidation - Nom commun

• (Virologie) Processus par lequel le matériel génétique d'un virus est emballé à l'intérieur de sa capside.

  À l’inverse, l’encapsidation est un processus un peu plus complexe dans la mesure où il existe deux ARN de taille génomique.

Encapsidation - Définition de France Terme

• Empaquetage de matériel génétique à l'intérieur d'une capside virale.

Étymologie de « encapsidation »

Évolution historique de l’usage du mot « encapsidation » depuis 1800

Citations contenant le mot « encapsidation »

• Upon investigating Mulch and Flayer–the satellite-helper phage systems, scientists found that satellites lacked certain replication genes but had encapsidation machinery. Flayer also has a unique tail adaptation for co-infection with its helper.

• Schematic of the ‘selective endogenous encapsidation for cellular delivery’ (SEND) system. PEG10, cargo RNA and fusogen vectors are transfected into cells. Inside cells, the PEG10 proteins pack the cargo mRNA and assemble into virus-like particles (VLPs) that are secreted to the growth medium in extracellular vesicles. The medium is then collected and the VLPs are isolated by ultracentrifugation. Finally, the target cells are transfected with the VLPs. Portions of this figure were created with BioRender.com.

• To treat chronic hepatitis B, class I CAMs induce hepatitis B virus (HBV) core protein (HBc) aggregation and sustained HBsAg reduction in AAV-HBV mice, in addition to inhibiting HBV RNA encapsidation and formation of infectious HBV particles. Antiviral activity on HBV DNA was determined in HepG2.117 cells using quantitative PCR. Both the primary effect on HBV DNA and the secondary effect on covalently closed circular DNA (cccDNA) establishment were studied in HBV-infected primary human hepatocytes (PHHs). Inhibition over several orders of magnitude was assessed in an optimized log drop assay.

• The Visalli laboratory uses Varicella-zoster virus as a model organism to understand the mechanism of viral genome (DNA) processing and packaging (i.e. encapsidation). He is interested in the function of proteins that form the encapsidation machinery (i.e. the terminase and portal proteins), portal structure and the identification of antivirals that inhibit DNA encapsidation.

• To investigate this, the scientists studied the faba bean necrotic stunt virus, which has eight distinct genome segments, and used fluorescent probes to detect the presence of the different viral segments in individual cells of the faba bean plants. Interestingly, the team found that distinct segments are most often found in different cells. This even applied to segments of the genome that code for vital functions such as replication, encapsidation (the process of enclosing viral DNA in a protective coat) and movement of the virus between cells.

Traductions du mot « encapsidation »

Sources et ressources complémentaires

• Définitions du Wiktionnaire
• Définitions du France Terme