Azathioprine

Définitions de « azathioprine »

Azathioprine - Nom commun

• (Pharmacie) Prodrogue de la 6-mercaptopurine, utilisée pour ses propriétés immunosuppressives et antinéoplasiques.

  La toxicité de l’azathioprine est hépatique et médullaire. L’azathioprine est responsable d’hépatiques cholestatiques réversibles, de pélioses, de maladies veino-occlusives ou d’hyperplasie nodulaire régénérative du foie.

Étymologie de « azathioprine »

Évolution historique de l’usage du mot « azathioprine » depuis 1800

Citations contenant le mot « azathioprine »

• Depuis qu’elle prend de l’azathioprine, Véronique Poirier arrive à contrôler sa maladie, mais elle remarque en effet qu’elle attrape beaucoup plus souvent le rhume ou la grippe. 

• The primary endpoint of biochemical remission at 24 weeks, defined as serum levels of alanine aminotransferase and immunoglobulin G below the upper limit of normal, was met in 56.4 percent of patients assigned to mycophenolate mofetil and in 29.0 percent assigned to azathioprine (difference, 27.4 percentage points, 95 percent confidence interval [CI], 4.0–46.7; p=0.022). [EASL 2023, abstract LBO-06]

• “First line treatment [of autoimmune hepatitis] consists of the combination of azathioprine with prednisolone, and these recommendations are based on clinical trials executed in the ’60s and ’70s,” Romée JALM Snijders, MD, a PhD candidate in the department of gastroenterology and hepatology at Radboud University Medical Center in the Netherlands, said. “Mycophenolate mofetil (MMF) has emerged as an alternative option to azathioprine. ... MMF has shown particularly favorable outcomes in patients intolerant to azathioprine and prospective studies have shown good results and promising results regarding the efficacy and safety of MMF.”

• “We need steroids, because autoimmune hepatitis is very responsive to a steroid, but also because azathioprine takes about 2-3 months to have full effects,” Martinez said. “There are other medications that can be used that work faster, like cyclosporine or tacrolimus. These are medications that are more familiar for doctors that treat patients with transplants, but actually that are very effective also for the treatment of autoimmune hepatitis.”

• A total of 134 patients experienced at least one relapse, for a total of 195 relapses, 102 of which were major. Time to a major relapse was a median 11 months shorter for patients on azathioprine than for those on rituximab (25 vs. 36 months), regardless of the regimen.

• The researchers further assessed the strength of their findings by conducting an active comparator analysis of TNF inhibitor monotherapy versus azathioprine monotherapy. TNF inhibitor use was associated with a significantly increased risk for IMIDs when compared with use of azathioprine (HR 2.94, 95% CI 2.33-3.70).

Traductions du mot « azathioprine »

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