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Il y a 40 citations sur le structural.
We can understand from Fig. 1 both the detailed assignments in the operational RNA code and their structural basis. Remarkably, the acceptor stem code is much the same as the universal genetic code (11). Nature moved the bases that first signaled AARS binding to the acceptor-stem into a new anticodon stem-loop. That major event may have arisen via doubling and end-to-end joining of minihelix genes (14,15). Open Access Government — tRNA: The operational RNA code and protein folding
What's more, the itaconyl-CoA/coenzyme B12 reaction produced a stable biradical that lingered for more than an hour instead of disappearing rapidly. This enabled lead author Markus Ruetz, Ph.D., of the department of biological chemistry in collaboration with the structural biology group led by Markos Koutmos, Ph.D., of the department of chemistry at U-M to grow crystals of the enzyme containing the biradical and obtain its 3-D structure. Immune system targets vitamin B12 pathway to neutralize bacteria
Here is a problem that can occur on trees of all sizes: The trunk splits apart below two stems of roughly equal size. In arborist lingo it is “failure of the attachment of codominant stems.” I have seen it in many tree species, from young fruit trees up to large coastal redwoods. Two stems of roughly equal diameter cannot get a good grip on each other. It is a structural defect that can be prevented if it is treated early on. All too often, it goes unnoticed until it becomes urgent. The Napa Valley Register — Bill Pramuk, Trees and People in Napa Valley: What to do with a splitting tree
P&D Environmental were contracted to carry out important cofferdam inspections on behalf of RG Parkins Ltd who are a leading structural and civil engineering consultancy based in the northwest of England. RG Parkin instructed P&D Environmental to carry out the works on behalf of their client, Associated British Ports (ABP) who are the UK’s leading and best-connected port owner and operator, with a network of 21 ports handling around a quarter of the UK’s seaborne trade. Constructive cooperation on important cofferdam inspections
The cyclobutane structural motif is present in a variety of natural products and pharmaceutical molecules Chemistry World — Flexible route to enantiomerically enriched cyclobutanes | Research | Chemistry World
The researchers discovered that iASPP had a previously unknown role in controlling desmosomes – one of the main structures that 'glue' individual heart muscle cells (cardiomyocytes) together. The genetic defect was shown to weaken desmosome function at the junctions of heart muscle cells: this affected the structural integrity of the heart, making mice lacking iASPP prone to ARVC. Protein clue to sudden cardiac death | University of Oxford
p.P187S binds FAD and dicoumarol (a competitive inhibitor of NADH) with ~10–100 fold lower affinity than the WT enzyme20,21 (Table 1). To explain these alterations in binding affinity at the structural and dynamic levels, we have compared the flexibility (B-factors) and secondary structure propensities of p.P187S and WT NQO1 from our MD trajectories (Fig. 4F–J). It is worth noting that changes in either the ligand-free or the ligand-bound conformational ensembles are expected to affect the ligand binding affinity. Nature — Conformational dynamics is key to understanding loss-of-function of NQO1 cancer-associated polymorphisms and its correction by pharmacological ligands | Scientific Reports
The results of Sumikama and Irie’s colleagues provide an important step forward towards a full understanding of the mechanism of divalent cation block in NavAb, an important and representative sodium ion channel. Quoting the scientists: “… our results and methods of structural analysis and molecular dynamics simulations are … expected to play an active and meaningful role in the advanced analysis of divalent cation-blocking mechanism.” EurekAlert! — Ion channel block unraveled | EurekAlert!
In this study, structural and functional analyses of EcOpgD and EcOpgG were performed. We discovered that EcOpgD is a β-1,2-glucanase (SGL, “S” is derived from sophoro-oligosaccharide, an alternative name of β-1,2-glucooligosaccharide) with a unique reaction mechanism, thereby establishing a new GH family (GH186) that is a phylogenetically new group, indicating that novel glycoside hydrolases are involved in OPG biosynthesis. Comparing the EcOpgD structure with EcOpgG with low SGL activity provided insights into the diversity of the functionally important region for hydrolysis by this GH family. Nature — Identification of enzymatic functions of osmo-regulated periplasmic glucan biosynthesis proteins from Escherichia coli reveals a novel glycoside hydrolase family | Communications Biology
Nakano, Y., Noda, K., Endo, T., Kobata, A. & Tomita, M. Structural study on the glycosyl-phosphatidylinositol anchor and the asparagine-linked sugar chain of a soluble form of CD59 in human urine. Arch. Biochem. Biophys. 311, 117–126 (1994). Nature — Cross-talks of glycosylphosphatidylinositol biosynthesis with glycosphingolipid biosynthesis and ER-associated degradation | Nature Communications
The heptose sugar maintains the structural integrity of the outer membrane of bacteria and interacts with membrane proteins and divalent cations. The heptose sugar is observed in inner core of lipopolysaccharide of E. coli and P. aeruginosa1. The heptose moiety is involved in ionic interactions and provides barrier to the passage of detergent, dyes and antibiotics through bacterial cell wall2 and is essential for survival of P. aeruginosa3. Nature — Structural and functional characterization of M. tuberculosis sedoheptulose- 7-phosphate isomerase, a critical enzyme involved in lipopolysaccharide biosynthetic pathway | Scientific Reports
Both forms of molecular memory are enabled by the CaMKII holoenzyme structure, which is assembled by the association of 12 subunits via their C-terminal association domains (also termed hub domains). GluN2B binding is mediated by the kinase domain, but is dramatically more efficient for holoenzymes compared with monomers6,9,10. T286-autophosphorylation occurs as an inter-subunit reaction within the holoenzyme, by a mechanism that enables frequency-detection by CaMKII (refs 11, 12, 13). Additionally, holoenzyme formation is thought to enable structural functions of CaMKII (refs 14, 15, 16). Nature — The CaMKII holoenzyme structure in activation-competent conformations | Nature Communications
Future work will focus on design structurally diverse chiral POMOFs and optimizing such reactions. The structural simplicity of catalyst and the use of inexpensive and readily available chemical reagents render this approach highly promising for the development of practical homochiral materials for asymmetric catalytic reactions. Nature — Polyoxometalate-based homochiral metal-organic frameworks for tandem asymmetric transformation of cyclic carbonates from olefins | Nature Communications
Ohshima, T. Structural characteristics of active and inactive glutamate dehydrogenases from the hyperthermophile Pyrobaculum islandicum. Biosci. Biotechnol. Biochem. 76, 1601–1610 (2012). Nature — Conformational changes in the catalytic region are responsible for heat-induced activation of hyperthermophilic homoserine dehydrogenase | Communications Biology
More information: Ling Xu et al, Structural insights into intron catalysis and dynamics during splicing, Nature (2023). DOI: 10.1038/s41586-023-06746-6 Scientists reveal how RNA gets spliced correctly
Taken together, the results demonstrate that MyBP-C is a fundamental element in regulating both thin and thick filament activation, actomyosin interaction, cross-bridge kinetics, force generation, and sarcomere integrity. Perhaps it is by selective adaptation that the protein keeps myosin heads in a structurally and biochemically favorable state, according to the muscle’s demands, and thus exerts a dual regulatory effect: inhibition and activation of the striated muscle. Despite significant efforts, we still do not understand the underlying functional and structural roles of MyBP-C or how it modulates myofilament performance. Nature — Etiology of genetic muscle disorders induced by mutations in fast and slow skeletal MyBP-C paralogs | Experimental & Molecular Medicine
An international team of researchers has used time-resolved ultrafast crystallography to follow the progress of DNA repair by a photolyase enzyme. The work is ‘the first structural characterisation of a full enzyme reaction cycle,’ says Manuel Maestre-Reyna, who led the research. Chemistry World — Molecular movie captures DNA repair from start to finish | Research | Chemistry World
Une récente réémergence de l’épidémie de Mpox ou « variole du singe » a révélé les poxvirus comme des menaces possibles en santé publique, soulignant dans le même temps, le manque de connaissances à leur sujet. En « plongeant » jusqu'au cœur des poxvirus pour décrypter l'architecture du noyau du virus, ces virologues et scientifiques de l’Institute of Science and Technology Austria (ISTA) apportent, dans la revue Nature Structural & Molecular Biology, de précieuses clés pour de nouveaux traitements. santé log — VARIOLE du SINGE : Ils décryptent le noyau du poxvirus | santé log
Kim, S. Y. et al. Structural basis for cold adaptation. Sequence, biochemical properties, and crystal structure of malate dehydrogenase from a psychrophile Aquaspirillium arcticum. J. Biol. Chem. 274, 11761–11767 (1999). Nature — Psychrophilic enzymes: hot topics in cold adaptation | Nature Reviews Microbiology
Hackmanite changes its color from white to purple under UV irradiation and eventually reverts back to white if no UV is present. The structural features enabling such repeated changes have so far been unclear. Now, upon investigating three natural minerals - hackmanite, tugtupite and scapolite – the researchers have found the answer. EurekAlert! — Natural mineral hackmanite can change color a | EurekAlert!