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1964. Lead scientist, Jerome P. Horwitz, working on new cancer treatments developed azidothymidine in 1964. Their work was funded by the National Cancer Institute (NCI, Grant #’s CY-5943 and CA-02903), one of the institutes within the publicly-funded US National Institutes of Health (NIH). Speaking of Research — What is failure? Shelved cancer treatment becomes first effective AIDS/HIV treatment – Speaking of Research
One of the AIDS treatments promoted by Dr. Fauci and his agency, the National Institute of Allergy and Infectious Disease (NIAID), was azidothymidine (AZT), a powerful and toxic chemotherapy drug used widely for AIDS patients despite the availability of less toxic options. AZT, according to SPIN magazine, is a drug that “was worse than the disease, and killed faster than the natural progression of AIDS left untreated. AZT had been an abandoned cancer drug, discarded because of its fatal toxicity, resurrected in the cynical belief that AIDS patients were going to die anyway, so trying it out was sort of like playing with the house’s money.” GlobeNewswire News Room — CHD’s Robert F. Kennedy, Jr. Reveals Fauci’s AIDS Bungling
The wonder drug azidothymidine (AZT) of 1987, which we thought was the magic bullet, turned out to be only minimally effective on its own against the virus. In 1987, it was discovered that latex condoms were effective in preventing the transmission of the virus, a major advancement. By 1991, similar drugs to AZT, like didanosine, were discovered and released. Three more drugs were released by 1995. They were all from the same class of drugs nucleoside reverse transcriptase inhibitors, or "nukes". Looking back at HIV | Health | Jamaica Gleaner
Lahaina’s giant banyan tree, scorched by the flames of Maui’s deadly wildfires, is showing small signs of recovery: sprouting a batch of fresh green leaves. To locals, the sprawling banyan is “a symbol of hope.” https://t.co/v9p8lZktFh pic.twitter.com/Y4wlFzz6I7 CNEWS — HawaÏ : carbonisé pendant de violents incendies, un arbre vieux de 150 ans repousse | CNEWS
The Cotswolds barn was converted by the practice, led by architect Carl Turner, in 2020 into a seven-bedroom holiday home for Laura and David Johnston, founder of the London design studio Accept & Proceed. Their brief was for an adaptable retreat that combines industrial and utilitarian agricultural architecture with modern minimalism. The Spaces — A converted Dutch barn by Turner Works comes to market in the Cotswolds - The Spaces
This recall involves compact bassinets that were sold individually or as an accessory to the Peg Perego YPSI and Z4 stroller systems. The bassinets have a zip-on boot, insert pad and a foldable canopy. The Z4 bassinets have an “Agio” label on the side of the canopy. Only bassinets manufactured on or after June 23, 2022 are included in this recall. The manufacture date in YYYY/MM/DD format and model number are located in the hood/head area of the bassinet and can be found by lifting the bassinet’s pad/cushion and internal lining. The YPSI and Z4 bassinets were sold in the following colors and model numbers, located beneath the date code: U.S. Consumer Product Safety Commission — Peg Perego Recalls Inclined Sleeper Bassinets for YPSI and Z4 Strollers Due to Risk of Suffocation and Fall Hazard; Violation of Federal Safety Standards (Recall Alert) | CPSC.gov
Basting is a culinary practice steeped in tradition, with many chefs and home cooks swearing by its ability to keep poultry moist and flavorful during roasting. The principle behind basting is that by regularly coating the chicken with its own juices or a marinade, the meat will retain moisture and the skin will achieve a desirable golden-brown color. But is basting really a thing you need to do when cooking a whole chicken? Is the end result really worth the extra effort? The Daily Meal — Is Basting Your Chicken Worth The Extra Effort?
U.S. District Court Judge Joanna Seybert said she changed the sentence she intended to give Mathew James from 10 years to 12 after being reminded by prosecutors that the 56-year-old medical biller may be eligible for a federal program that would allow for a sentence reduction if given 10 years. Newsday — Sentencing of LI medical biller in $600 million health care scheme put off - Newsday
The European Court of Justice has annulled the previous approval for 3.4 billion euros of state aid that KLM received during the coronavirus crisis, declaring it illegal state aid. The case was filed by the airline Ryanair, which considered the COVID-19 support from the Dutch government unfair competition. NL Times — €3.4 billion in coronavirus support to KLM was illegal state aid, EU court rules | NL Times
New York, Feb. 07, 2024 (GLOBE NEWSWIRE) -- The global nuclear medicine market size is predicted to expand at ~20% CAGR between 2023 and 2033. The market is projected to garner a revenue of USD 20 billion by the end of 2033, up from a revenue of ~USD 9 billion in the year 2022.The growth of this sector is set to be dominated by the rising prevalence of cardiovascular disease. As per the predictions of the World Health Organization, an estimated 17.9 million people worldwide lose their lives to cardiovascular diseases (CVDs), making them the top cause of death worldwide. Therefore, the market is poised to grow. GlobeNewswire News Room — Nuclear Medicine Market revenue to surpass USD 20 Billion
The record for being the fastest to recall 50 binomial scientific names was set by Muhammathu Hisham. A (born on April 28, 2017) of Dindigul, Tamil Nadu. He recalled 50 binomial scientific names of different fruits, vegetables and animals in 1 minute and 11 seconds at the age of 6 years and 5 months, as confirmed on September 28, 2023. IBR — Fastest kid to recall 50 binomial scientific names - IBR
Benthic organisms are therefore the "gardeners" of the ocean floor. And they help to maintain a healthy ecosystem. By bringing oxygen into the sediments, bioturbation allows many organisms to establish themselves there. It also increases biodiversity and promotes the decomposition of organic matter while reducing the concentration of potentially toxic waste, such as hydrogen sulfide. Researchers: Oxygen in the St. Lawrence Estuary is decreasing and having a major impact on small animals living there
Democrats had argued the bill was politicized because a bipartisan group of senators has already agreed to a separate package that addresses aid to Israel, as well as the southern border and aid to Ukraine. Republicans, led by former President Donald Trump, have rejected that deal. CNBC — House rejects Israel aid bill amid fight over bipartisan border package
But, James says, he connects with our biracial culture just by being himself. KUOW - 'I wonder if people think you took that baby.' Navigating Seattle as a biracial family
We Rip the World Apart tells the layered story of Kareela, a 24-year-old, biracial woman, who finds out she's pregnant and is struggling to find herself; her mother, Evelyn, who fled to Canada from Jamaica in the 1980s; and her paternal grandmother, Violet, who moved into their house after Kareela's brother was killed by the police. CBC — Charlene Carr explores Black and biracial identity in the Maritimes with her novel We Rip the World Apart | CBC Radio
As biracial Japanese stars such as Rui Hachimura and Naomi Osaka shine on the world stage, being Black and Japanese is having a moment. I ventured to Japan on a yearlong contract with the Japan Exchange and Teaching program in 2005, which has turned into an 18-year journey, marked by my marriage to a Japanese woman and the arrival of my three children — two boys and a girl. Business Insider — Here's Why Raising Biracial Kids in Japan Is Better Than in the US
Previous standard DFT results on the reactivity between CH3 and HCO on amorphous water surfaces, showed that formation of CH4 + CO by H transfer from HCO to CH3 assisted by water molecules of the ice was the dominant channel. However, the adopted description of the electronic structure of the biradical (i.e., CH3/HCO) system was inadequate (without the broken-symmetry (BS) approach). In this work, we revisit the original results by means of BS-DFT both in gas phase and with one water molecule simulating the role of the ice. Astrobiology — Revisiting The Reactivity Between HCO and CH3 On Interstellar Grain Surfaces - Astrobiology
What's more, the itaconyl-CoA/coenzyme B12 reaction produced a stable biradical that lingered for more than an hour instead of disappearing rapidly. This enabled lead author Markus Ruetz, Ph.D., of the department of biological chemistry in collaboration with the structural biology group led by Markos Koutmos, Ph.D., of the department of chemistry at U-M to grow crystals of the enzyme containing the biradical and obtain its 3-D structure. Immune system targets vitamin B12 pathway to neutralize bacteria
Ethiopia may be set for a phased devaluation of the birr to secure an IMF bailout agreement by the end of March, economists say. The Africa Report.com — Ethiopia’s birr valuation unlikely to survive negotiations on IMF support package - The Africa Report.com
“International actors,” he says, however, “who may not be an official participant in this informal conference in Geneva can, in this confluence of events, play a decisive part and contribute to achieve positive developments.” Christodoulides also discusses remarks about a confederation and a two-state solution, rejecting a change in the model to settle the issue and highlighting that the only basis for a solution is that of a bizonal bicommunal federation. “A confederation requires recognizing a separate state in the occupied territories, which by extension, would derecognize the Republic of Cyprus.” A failure of Geneva talks would serve no one, Cyprus foreign minister tells Kathimerini | eKathimerini.com